Dimethyl malonate

Research use only, not for human use.

Dimethyl Malonate is a Succinate Dehydrogenase inhibitor.

Dimethyl Malonate is a Succinate Dehydrogenase inhibitor.

——

Animal Model:Sprague-Dawley male rats, cardiac arrest modelDosage:6 mg/kg/minAdministration:Intravenous infusion, 51 minResult:Improved ROSC after CA. Prevented the decline in neurological function and inhibited the apoptosis of hippocampal neurons at day 3 after CPR. Inhibited caspase-3 cleavage and increased HIF-1α expression at day 3 after CPR. Decreased the level of oxidative stress at day 3 after CPR. Inhibited excessive hyperpolarization of MMP and restrained the leakage of cytochrome C after 45 min reperfusion.

——

Others

Other Targets

Succinate Dehydrogenase

——

——

108-59-8

132.11

C5H8O4

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (756.94 mM)

COC(=O)CC(=O)OC

——

(-20℃)

With Ice Pack

≥ 2 years